News Release 2004

• December 1, 2004Kyorin Pharmaceutical Announces Signing of Acquisition Agreement of ActivX Biosciences
• October 25, 2004Conclusion of license agreement for IBUDILAST with MEDICINOVA
• September 7, 2004Launch of GATIFLO 0.3% Eye Drops,a Broad-spectrum,Antibacterial Ophthalmic Solution,in Japan
• August 19, 2004Kyorin Executes Patent License and Collaborative Research and Development Agreement with Merck & Co., Inc.
• March 24, 2004Kyorin Announces the Filing of a Lawsuit for Patent Infringment Aganist TEVA in the United States