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Conclusion of license agreement for IBUDILAST with MEDICINOVA

October 25, 2004

KYORIN Pharmaceutical Co., Ltd. (President: Ikuo Ogihara) announces that it has concluded the License Agreement with MediciNova, Inc., a U.S. corporation (President & CEO: Takashi Kiyoizumi, M.D., Ph.D.) for Ibudilast (Brand Name: Ketas® Capsule) which KOYRIN originated for bronchial asthma and cerebrovascular disorders under the following principal terms

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