News Release 2004

• December 1, 2004

  Kyorin Pharmaceutical Announces Signing of Acquisition Agreement of ActivX Biosciences

• October 25, 2004

  Conclusion of license agreement for IBUDILAST with MEDICINOVA

• September 7, 2004

  Launch of GATIFLO 0.3% Eye Drops,a Broad-spectrum,Antibacterial Ophthalmic Solution,in Japan

• August 19, 2004

  Kyorin Executes Patent License and Collaborative Research and Development Agreement with Merck & Co., Inc.

• March 24, 2004

  Kyorin Announces the Filing of a Lawsuit for Patent Infringment Aganist TEVA in the United States

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